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Watch Intently (one)pentobarbital will lower the level or effect of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your lessen in fentanyl plasma concentrations, insufficient efficacy or, maybe, enhancement of the withdraw